Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model

Table 2 Pharmacokinetics of intravenous artelinate and artesunate in plasma from P. coatneyi infected rhesus monkeys

Pharmacokinetics		Rx	Parent compound (P)				Metabolite (M)				M/P	% AUC_0–20
Parameter	Unit	Rx	Median	25th IQT	75th IQT	p^a	Median	25th IQT	75th IQT	p^a	M/P	AUC_0–∞
C ^b_max	mM	IV AL	60.2	55.9	65.3	<0.0001	10.9	9.10	13.4	<0.0001	0.18
C ^b_max	mM	IV AS	28.2	24.3	38.0	<0.0001	7.23	6.52	7.41		0.26
t ^c_1/2	min	IV AL	28.2	25.8	35.4	<0.0001	42.2	33.2	47.6	0.02	1.50
t ^c_1/2	min	IV AS	3.47	3.09	5.15	<0.0001	31.1	25.0	34.5	0.02	8.97
AUC ^d_0–∞	mM min	IV AL	3706	2845	4218	<0.0001	1260	944	1519	<0.0001	0.33
AUC ^d_0–∞	mM min	IV AS	288	260	399	<0.0001	453	415	494	<0.0001	1.58
AUC ^e_0–20	mM min	IV AL	925	849	1028	<0.0001	117	100	153	0.7		24.6
AUC ^e_0–20	mM min	IV AS	288	253	394	<0.0001	116	107	122	0.7		97.0
Cl^f	L kg⁻¹ min⁻¹	IV AL	5.60	4.85	7.88	<0.0001
Cl^f	L kg⁻¹ min⁻¹	IV AS	72.3	52.4	79.9	<0.0001
V ^g_z	L kg⁻¹	IV AL	0.259	0.241	0.294	0.07
V ^g_z	L kg⁻¹	IV AS	0.397	0.311	0.507	0.07

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