Author, year and country | Epidemiology (baseline parasitemia) | Study type | Anti-malarial | Additional interventions |
---|---|---|---|---|
Butler 1943, South Pacific [36] | 12–16% | Before and after Study was largely a review of the Us Navy’s malaria control program implemented on an unspecified occupied island in the South Pacific. Natives of 2 villages were recruited into the study | Mepacrine | NR |
Berberian 1948a, Lebanon [26] | NR | Non-RCT All persons aged above 6Â months of Saideh village | Chloroquine | NR |
Chaudhuri 1950a, India [83] | 50% | Non-RCT Only children were participants in the study | Proguanil | NR |
Edeson 1957, Malaysia [84] | 29% | Non-RCT All ages except infants. Inhabitants of rural rice growing area of Negri Sembilan state | Proguanil | NR |
Gabaldon 1959, Venezuela [39] | 0.24% | Before and after Population of eastern and western Venezuela. All persons aged >1 month | Pyrimethamine | IRS with DDT |
Clyde 1961a, Tanzania [32] | Morbidity rate: 76.1% Parasitemia in european children: 11.5% | Before and after Europeans living in Tanga | Quinine | Bed nets |
Charles 1962, Ghana [33] | 55.3% | Before and after All aged residents of Akrofu villages | Pyrimethamine | NR |
Sehgal 1968, India [37] | 1.8% | Before and after All individuals except the very sick, old and the pregnant women | NR | Irs with ddt |
Omer 1978, Sudan [85] | 40.5% | Non-RCT All residents of 4 villages in Gezira ecological area of Northern Sudan | Chloroquine | NR |
Maccormack 1983, Tanzania [47] | NR | Non-RCT The age range of the participants was 0–15 years | Chloroquine | NR |
Dapeng 1996, China [38] | 0.8/1000 population/month in 1984 | Before and after All residents within high incidence areas in 4 counties in Xinyang prefecture | Chloroquine + primaquine | Irs with ddt, itns |
Song 2010, Cambodia [43] | 2–50% | Before and after All residents above 1 year from 17 villages with parasite rates 20% or higher in Kampong Speu Province | Artemisinin + piperaquine + primaquine | NR |