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Table 2 Five studies assessing the safety of ivermectin during pregnancy compared with community based controls

From: Ivermectin to reduce malaria transmission I. Pharmacokinetic and pharmacodynamic considerations regarding efficacy and safety

Reference

Country

Number of pregnant women

Number inadvertently treated

In the first trimester

Pregnancy outcome

Child mortality

Child development

Pacque et al. [81]

Liberia

939

200

171 (85%)

No difference with controls

No difference with controls

No difference with controls (follow-up 2 years)

Doumbo et al. [102]

Mali

461

82

Not stated

Data not readily assessable

Chippaux et al. [103]

Cameroon

511

110

(93) 85%

No difference with controls

No difference with controls

No difference with controls (follow-up 1 year)

Gyapong et al. [104]

Ghana

343

50

(50) 100%

No difference with controls

No difference with controls

No difference with controls (follow-up not stated)

Ndyomugyenyi et al. [105]

Uganda

834

397a

All in 2nd trimester

No difference with controls

No difference with controls

Not included

  1. a Clinical trial