Fig. 1

Newly predicted domain architecture of P. falciparum gene PF3D7_1369500. Plasmobase “Look up” page associated to gene PF3D7_1369500. CLADE predicted architecture (top) contains three domains: MIF4G, MIF4G_like_2, MIF4G_like. Pfam_27 architecture is displayed below and it highlights no identified domains. The list of all domains identified by CLADE is given. Besides the three domains belonging to CLADE architecture, there is one more domain displayed in grey that has been also identified by CLADE but not selected by DAMA. The user might be interested to consider it in view of a putative functional annotation of the protein. Indeed, he/she can select a combination of CLADE domains and explore it either in Plasmobase or in UniProt by clicking on the corresponding buttons (bottom). The list of orthologs and paralogs, according to PlasmoDB, can be displayed by clicking on the “show” link. Windows with informations on identified domains (Pfam domain name, Pfam accession number, CLADE model species, position of the domain in the protein, domain coverage, E-value, CLADE SVM probability, clan name if any) are accessible by passing the mouse above the domain location, as illustrated by the information box for the blue domain. Note that the clade-centred model generated by the Bombix mori MIF4G_like sequence is the one that obtained the best match with Plasmodium sequence PF3D7_1369500