Table 1 Ex vivo susceptibilities of 215 African Plasmodium falciparum isolates to chloroquine (CQ), quinine (QN), monodesethylamodiaquine (DQ), mefloquine (MQ), lumefantrine (LMF), piperaquine (PPQ), pyronaridine (PND), dihydroartemisinin (DHA), artesunate (AS) and doxycycline (DOX) according to the D113N mutation in the RING E3 ubiquitin protein ligase (PF3D7_0627300) gene
Drug | Wild-type D113 (31.6%) | Mutated 113N (68.4%) | p valuec | ||
|---|---|---|---|---|---|
Mean IC a50 | Min and maxb | Mean IC50 | Min and maxb | ||
CQ | 75.5 | [6.3–791.6] | 75.1 | [11.7–615.9] | 0.933 |
QN | 128.2 | [5.3–631] | 124.8 | [9.5–690.1] | 0.824 |
DQ | 30.3 | [1.9–251.5] | 30.4 | [6.3–196.4] | 0.830 |
MQ | 32.9 | [5.5–173.4] | 40.2 | [2.4–172.6] | 0.225 |
LMF | 1.33 | [0.4–15.1] | 1.35 | [0.33–16.7] | 0.532 |
PPQ | 31.9 | [6.8–128.7] | 34.0 | [7.5–127.5] | 0.398 |
PND | 17.1 | [1.67–89.2] | 15.7 | [0.8–123.0] | 0.896 |
DHA | 4.02 | [0.09–21.1] | 3.90 | [0.2–28.1] | 0.646 |
ASU | 3.64 | [0.21–23.6] | 3.57 | [0.1–21.2] | 0.851 |
DOX | 16.8 | [0.46–51.1] | 16.4 | [0.79–49.9] | 0.463 |