Antibody levels to recombinant VAR2CSA domains vary with Plasmodium falciparum parasitaemia, gestational age, and gravidity, but do not predict pregnancy outcomes

Table 4 Regression analysis of mean antibody levels to 11 VAR2CSA domains during pregnancy and at delivery on birth weight and gestational age

Sampling time	Outcome	Gravidity^a	OR (95% CI)	p value
Enrollment	LBW	Primigravid	1.84 (0.43–9.20)	0.4
	LBW	Multigravid	0.84 (0.30–2.53)	0.7
	SGA	Primigravid	1.97 (0.62–7.093)	0.3
	SGA	Multigravid	0.58 (0.25–1.44)	0.2
Gestational week 30–32	LBW	Primigravid	7.06 (0.61–131.45)	0.1
	LBW	Multigravid	0.72 (0.23–2.45)	0.6
	SGA	Primigravid	1.36 (0.24–8.50)	0.7
	SGA	Multigravid	0.69 (0.27–1.99)	0.5
Delivery	LBW	Primigravid	3.34 (0.70–19.47)	0.2
	LBW	Multigravid	0.66 (0.25–1.87)	0.4
	SGA	Primigravid	2.34 (0.59–11.11)	0.3
	SGA	Multigravid	0.76 (0.34–1.88)	0.5

Sampling time	Outcome	Gravidity	β	p value
Enrollment	BW	Primigravid	− 0.14	0.02
	BW	Multigravid	0.02	0.7
	GA	Primigravid	− 0.77	0.07
	GA	Multigravid	− 0.05	0.8
Gestational week 30–32	BW	Primigravid	− 0.16	0.07
	BW	Multigravid	− 0.01	0.8
	GA	Primigravid	− 0.84	0.1
	GA	Multigravid	0.24	0.2
Delivery	BW	Primigravid	− 0.13	0.03
	BW	Multigravid	− 0.02	0.7
	GA	Primigravid	− 0.53	0.2
	GA	Multigravid	− 0.02	0.9

Models were adjusted for malaria infection, number of IPTp doses and ITN. The analyses of LBW and BW were also adjusted for gestational age
LBW low birthweight, SGA small for gestational age, BW birthweight, GA gestational age
^aPrimigravid, 1st pregnancy; Multigravid, ≥ 1 previous pregnancies

ISSN: 1475-2875