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Table 1 The survival rates of transgenic parasite lines with either F446I or C580Y mutation and their parental strains (mean ± SD)

From: Introduction of F446I mutation in the K13 propeller gene leads to increased ring survival rates in Plasmodium falciparum isolates

Strains/lines

RSA0–3 h at DHA 700 nM (%)

RSA0–3 h at DHA 20 nM (%)

3D7wt

0

3.15 ± 0.13

3D7C580Ymut

0.91 ± 0.11

33.08 ± 1.20

3D7F446Imut

0.73 ± 0.10

26.0 ± 1.48

Fcc1/HNwt

0

2.86 ± 0.44

Fcc1/HNC580Ymut

0.63 ± 0.07

17.5 ± 0.80

Fcc1/HNF446Imut

0.53 ± 0.06

13.5 ± 0.41

F08-27

8.27 ± 0.63

65.8 ± 4.06

  1. Each assay was repeated for three times independently, with each group setting three technical repetitions
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Malaria Journal

ISSN: 1475-2875

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