Prevalence of molecular markers of sulfadoxine–pyrimethamine and artemisinin resistance in Plasmodium falciparum from Pakistan

Table 3 Prevalence of K13-propeller domain mutations in clinical P. falciparum isolates from Pakistan

Mutant codon position	Type of mutation	Prevalence of mutation % (n)	References
C473Y	NS	0.7 (n = 1)	[44]
E509D	NS	0.7 (n = 1)	[47]
R513P	NS	0.7 (n = 1)	[48]
G544G	S	0.7 (n = 1)	[48]
P553P	S	0.96 (n = 2)	[49]
A557T	NS	0.7 (n = 1)	[50]
P615L	NS	0.7 (n = 1)	[44]
S624S	S	0.7 (n = 1)	*
V637I	NS	0.7 (n = 1)	[51]
G638R	NS	0.7 (n = 1)	[52]
L678L	S	0.7 (n = 1)	*
S679L	NS	0.7 (n = 1)	*
P701L	NS	0.7 (n = 1)	[53]

* Mutation not found in literature. Mutations in italics indicate amino acid positions where mutations have been observed previously, but different alleles were present at these positions in the samples from Pakistan compared to those reported in other geographic regions

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