Antiplasmodial natural products: an update

Tajuddeen, Nasir; Van Heerden, Fanie R.

doi:10.1186/s12936-019-3026-1

Malaria Journal

Table 2 Natural products with transmission-blocking potential

From: Antiplasmodial natural products: an update

Compound	Parasite	Active on	Activity	IC₅₀	References
Dihydronitidine	Plasmodium berghei	Early mosquito stage	Inhibition of ookinete formation	1.7 µM	[65]
Heitziquinone	P. berghei	Early mosquito stage	Inhibition of ookinete formation	17 µM	[65]
Mallotojaponin C	P. falciparum NF54	Stage V gametocytes	Gametocytocidal	3.6 µM	[232]
Carmaphycin B	P. falciparum NF54	Stage V gametocytes	Gametocytocidal	160 nM	[277]
Carmaphycin B	P. berghei	Liver stage		61.6 nM
Parthenine	P. falciparum NF54	Stage V gametocytes	Gametocytocidal. Inhibition of microgamete exflagellation. Prevent oocysts development in mosquito at 3.84 µM		[314]
		Early mosquito stage	Inhibition of ookinete formation	100% inhibition at 191 µM	[314]
Parthenolide	P. falciparum NF54	stage V gametocytes	Gametocytocidal. Inhibition of microgamete exflagellation. prevent oocysts development in mosquito at 4 µM		[314]
Deacetylnimbin	P. berghei	Early mosquito stage	Inhibition of ookinete formation	100% inhibition at 100 µM	[315]
Azadirachtin	P. falciparum NF54	Stage V gametocytes	100% inhibition of microgamete exflagellation		[316]
	P. berghei	Stage V gametocytes	Gametocytocidal. Inhibition of microgamete exflagellation	3.25 µM	[316]
Vernodalol	P. berghei	Early mosquito stage	Inhibition of early sporogenic stages development	18.7 µM	[310]
Vernolide	P. berghei	Early mosquito stage	9–33% inhibition of early sporogenic stages development at 50 µM		[310]
Usnic acid	P. berghei	Liver stage		2.3 µM	[295]
Vulpic acid	P. berghei	Liver stage		10.2 µM	[295]
Psoromic acid	P. berghei	Liver stage		31.6 µM	[295]
Evernic acid	P. berghei	Liver stage		77.3 µM	[295]
Balsaminol F	P. berghei	Liver stage	Inhibition of intracellular development	> 95% inhibition at 15 µM	[163]
BalsaminosideB	P. berghei	Liver stage	Inhibition of intracellular development	> 95% inhibition at 15 µM	[163]
Triacetylbalsaminol F	P. berghei	Liver stage	Inhibition of intracellular development	> 95% inhibition at 15 µM	[163]
6-Deoxy-8-O-methylrabelomycin	P. berghei	Liver stage		18.5 µM	[317]
X-14881 E	P. berghei	Liver stage		3.0 µM	[317]
Marilone A	P. berghei	Liver stage	Inhibition of liver cell infection	12.1 µM	[318]

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ISSN: 1475-2875

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