Identification of Plasmodium falciparum proteoforms from liver stage models

Winer, Benjamin; Edgel, Kimberly A.; Zou, Xiaoyan; Sellau, Julie; Hadiwidjojo, Sri; Garver, Lindsey S.; McDonough, Christin E.; Kelleher, Neil L.; Thomas, Paul M.; Villasante, Eileen; Ploss, Alexander; Gerbasi, Vincent R.

doi:10.1186/s12936-019-3093-3

Malaria Journal

Table 1 Uniprot accession number, amino acid sequence, sequence length, C-score, presence or absence in sporozoites, presence or absence in blood stages, PEXEL domain, IEDB immunogenicity score, and PlasmoDB (3D7) identification number of malaria proteoforms identified from > 1 biological replicate of humanized mouse livers infected with NF54 sporozoites

From: Identification of Plasmodium falciparum proteoforms from liver stage models

Protein name	Peptide sequence	Peptide length	C-score	Present in sporozoites (yes/no)	Present in blood stages (yes/no)	PEXEL domain	Immunogenicity score	PlasmoDB
Uncharacterized protein	LESQKKMKIFLLSYNIFQKMDNPVD	25	58.7	No	Yes	No	− 1.14019	PF3D7_0210500
26S proteasome regulatory subunit	YYINKKEIDKLIEFTTSNE	19	36.8	Yes	Yes	Yes	− 0.08337	PF3D7_1402300
Actin-2	WITKEEYEDSGPSIVHRK	18	1059.7	Yes	Yes	No	0.0321	PF3D7_1412500
DNA polymerase epsilon catalytic subunit A	FILNIDAYKWVERDSYLPNGSRTLKSVC	28	128.08	Yes	Yes	Yes	− 0.17081	PF3D7_0630300
Uncharacterized protein	RFTHILSIHIIE	12	222.1	Yes	Yes	No	0.35298	PF3D7_1108900
Uncharacterized protein	SYLEKHLKIEDLDECIKKKRND	22	106.3	No	Yes	No	− 0.45115	PF3D7_0622100
Uncharacterized protein	MSNILYVSILLLLYFLDLYS	20	34.2	No	Yes	No	0.19188	PF3D7_1452400
Uncharacterized protein	MVPKNILFIFVILFHLIGYLKN	22	222.7	No	No	No	0.56696	PF3D7_1336700
LCCL domain-containing protein	TKLFFINYAFVIIFSFNLFVKC	22	85	Yes	Yes	No	0.86824	PF3D7_1455800
Uncharacterized protein	TYVKIHEKLGSDFYNILHANII	22	17.8	No	Yes	No	0.09123	PF3D7_0612400
Uncharacterized protein	EKQKLVEEKQKLVDEKQNLIDE	22	56.7	Yes	Yes	No	− 0.62876	PF3D7_0903600
MSP7-like protein	IKGLIFYLFICFFVFFVHA	19	183.8	Yes	Yes	No	0.96628	PF3D7_1334600
Uncharacterized protein	PLYYEHKFSDLKIQQSYTP	19	109.2	Yes	Yes	No	− 0.56439	PF3D7_0728100
p1/s1 nuclease	SNIFVIFCSLLILIFTKRCSG	21	54.6	No	Yes	No	0.30636	PF3D7_1411900
Merozoite surface protein 8	VFKSSYIFFFLFLVILYFNNVVEG	24	84.4	Yes	Yes	No	0.55183	PF3D7_0502400
Uncharacterized protein	MPLLFFILLIIYFHLIVC	18	124.6	No	Yes	No	0.84834	PF3D7_0934000
Leucine–tRNA ligase	KKRSYVNWSNELRCVISNDELRNEINL	27	3	Yes	No	No	0.37112	PF3D7_0828200
SUN domain-containing protein	MIWWFLISVNFLFFLIKS	18	82.9	Yes	Yes	No	0.70747	PF3D7_1439300
Acetyl-CoA synthetase	KLKHIEIKK	9	139.5	Yes	Yes	No	0.17272	PF3D7_0627800
Uncharacterized protein	ISLFYSIYICLEKLCKK	17	47.9	Yes	Yes	Yes	− 0.15264	PF3D7_0809600

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ISSN: 1475-2875

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