Skip to main content

Table 4 Association between placental malaria and non-malaria outcomes in infants during the first year of life

From: Infant sex modifies associations between placental malaria and risk of malaria in infancy

Outcome measure

Placental malaria category (N)

Number of cases (incidence PPY)

Unadjusted

Adjusteda

IRR (95% CI)

p-value

IRR (95% CI)

p-value

Incidence of all-cause hospitalisations

No PM (351)

9 (0.027)

Reference group

Reference group

Active PM (78)

3 (0.044)

1.66 (0.40–7.00)

0.49

1.14 (0.22–5.98)

0.87

Past PM (mild-mod) (181)

7 (0.044)

1.72 (0.58–5.12)

0.33

1.26 (0.44–3.64)

0.66

Past PM (severe (46)

6 (0.141)

4.85 (1.38–17.00)

0.01

2.90 (0.59–14.44)

0.19

Incidence of non-malarial febrile illnesses

No PM (351)

1128 (3.45)

Reference group

Reference group

Active PM (78)

203 (2.95)

0.86 (0.72–1.03)

0.10

0.84 (0.64–1.10)

0.20

Past PM (mild-mod) (181)

536 (3.40)

0.98 (0.86–1.13)

0.82

1.03 (0.84–1.25)

0.79

Past PM (severe (46)

152 (3.58)

1.04 (0.85–1.26)

0.72

1.06 (0.72–1.57)

0.76

Prevalence measures

Categories

Prevalence n/N (%)

Risk ratio (95% CI)

p-value

Risk ratio (95% CI)

p-value

Anaemiac

No PM (351)

227/934 (24.3%)

Reference group

Reference group

Active PM (78)

48/190 (25.3%)

1.07 (0.76–1.50)

0.69

1.00 (0.69–1.47)

0.98

Past PM (mild-mod) (181)

106/441 (24.0%)

1.01 (0.80–1.29)

0.92

0.94 (0.73–1.22)

0.64

Past PM (severe (46)

37/118 (31.4%)

1.29 (0.94–1.77)

0.12

1.16 (0.79–1.70)

0.44

  1. CI confidence interval, IRR incidence rate ratio, mild-mod mild-moderate, PM placental malaria
  2. aAdjusted for gravidity, maternal IPTp, maternal parasitaemia at enrolment, and household type
  3. b Defined as haemoglobin < 10 g/dL measured routinely at 12, 28, and 52 weeks of age
  4. No PM no parasites or pigment detected, active PM parasites detected with or without pigment, past PM (mild-mod) > 0–20% of high-power fields with pigment but no parasites, past PM (severe) > 20%–60% of high-power fields with pigment but no parasites