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Table 2 Changes in the frequency of Pfcrt haplotypes between 1998 and 2020

From: Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998–2020)

Gene

Haplotype

1998–2004

(%, n/N)

2005–2010

(%, n/N)

2011–2016

(%, n/N)

 ≥ 2017

(%, n/N)

P-value

Pfcrt

CVMNK

7.7 (12/156)

20.0 (1/5)

56.1 (101/180)

40.2 (323/804)

P < 0.0001

Pfcrt

CVIET

57.1 (89/156)

0.0 (0/5)

36.7 (66/180)

57.9 (301/520)

P < 0.0001

  1. *P < 0.05: Statistically significant, n: Number of amino acid substitutions, N: Total number of samples genotyped
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Malaria Journal

ISSN: 1475-2875

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