Plasma angiopoietin-2 is associated with age-related deficits in cognitive sub-scales in Ugandan children following severe malaria

Table 5 Association between Angpt-2 level and longitudinal age-adjusted z scores over two years follow-up in children with a severe malaria episode at ≥ 5 years of age

	N (obs), N	Unadjusted LME Model¹		Adjusted LME Model^1,2
	N (obs), N	Beta (95% CI)	P	Beta (95% CI)	P	Significant †
Children ≥ 5 years of age at time of severe malaria episode (enrolment time point) (KABC-2)
Planning³	194, 84	− 0.13 (− 0.42, 0.16)	0.3783	− 0.16 (− 0.52, 0.20)	0.3844
Learning	343, 89	− 0.22 (− 0.63, 0.18)	0.2764	− 0.26 (− 0.72, 0.20)	0.2682
Sequential processing	344, 89	− 0.10 (− 0.60, 0.40)	0.6967	− 0.01 (− 0.59, 0.56)	0.9644
Simultaneous processing	343, 89	− 0.21 (− 0.59, 0.16)	0.2659	− 0.20 (− 0.62, 0.22)	0.3457

^†p < 0.05 in model after correction for multiple comparisons (n = 4 for children ≥ 5 years of age at enrolment)
¹Linear mixed effects (LME) model where observations within subject were correlated using a subject-specific intercept, and time points as categorical variables
² Models included age, gender, height-for-age z-score, socioeconomic status, home environment, parental education, preschool education of the child (any), presence of coma, number of seizures during admission, and acute kidney injury
³Planning is assessed in children ≥ 7 years of age

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