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Table 2 Distribution of pfk13 and pfcrt-K76T mutations

From: Assessment of Plasmodium falciparum anti-malarial drug resistance markers in pfk13-propeller, pfcrt and pfmdr1 genes in isolates from treatment failure patients in Democratic Republic of Congo, 2018–2019

Site

Positive PfPCR

N (%)

Pfcrt gene

pfK13 gene

Pf successfully sequenced

N

K76T

N

K76T

%

(95% CI)

Pf successfully sequenced

N

Mutant Pf

N

Mutant Pf

%

(95% CI)

NS mutation

Bolenge

70 (79.5)

62

21

33.9 (22.3–47.0)

60

2

3.3 (0.4–11.5)

F506L, N554K

Fungurume

63 (75.9)

60

6

10.0 (3.8–20.5)

58

1

1.7 (0.0–9.2)

A557S

Kabondo

17 (85.0)

16

3

18.8 (4.0–45.6)

17

0

0.0 (0.0–16.2)

Katana

95 (66.4)

91

70

76.9 (66.9–85.1)

86

2

2.3 (0.3–8.1)

N498I, D516E

Kingasani

92 (81.4)

81

27

33.3 (23.2–44.7)

80

2

2.5 (0.3–8.7)

E507V, G538S

Vanga

27 (100.0)

25

12

48.0 (27.8–68.7)

24

0

0.0 (0.0–11.7)

Total

364 (76.8)

335

139

41.5 (36.2–47.0)

325

7

2.2 (0.9–4.4)

 
  1. N number, PfPCR Plasmodium falciparum polymerase chain reaction, NS non-synonymous