Fig. 10

The approximate tafenoquine dose–response relationship (blue line) for prevention of P. vivax recurrence (180 days assessment) fitted by logistic regression to the data from the multinational DETECTIVE study; Llanos-Cuentas et al. [98]. Different doses of tafenoquine were given together with a standard 25 mg base/kg dose of chloroquine. As both relapse and recurrent infections are included, the true tafenoquine radical cure dose–response relationship has a steeper slope. The brown line shows the primaquine radical cure dose–response relationship (28 days assessment) from the study of different durations of primaquine in Thai adults with vivax malaria treated with artesunate shown in Fig. 5 [72]. Follow up for 28 days is insufficient to capture all relapses following artesunate so the true efficacy is slightly lower than portrayed