Fig. 11

(Left): An illustration of how shifts to the right in the dose- response relationship (such as would be associated with higher hypnozoite loads) are expected to have a significant effect on the radical curative efficacy of the tafenoquine 300 mg adult dose (from Fig. 10). (Right): A similar illustration of the approximate dose–response relationship for primaquine in Southeast Asian P. vivax (from Fig. 10). This indicates that right shifts would give a greater reduction in radical curative efficacy of the widely used primaquine adult total dose of 210 mg (15 mg base/day for 2 weeks or 30 mg/day for 1 week), than they would on the WHO recommended (but rarely followed) 420 mg adult total dose (30 mg base/day for 2 weeks or 60 mg/day for 1 week)