Author, year [Ref] | SNP | Country | Setting | Age group in cases,yr | Male % in cases | Cases | Controls | Genotyping method | Consistent with HWE |
---|---|---|---|---|---|---|---|---|---|
Mockenhaupt, 2006 [20] | TLR4-A299G, T399I TLR9 T-1237C, T1486C | Ghana | H | Children | 46.6 | 290 | UM: 290 Healthy: 290 | allele-specific PCR and PCR-RT | Yes |
Leoratti, 2008 [21] | TLR4 D299G TLR9 T1237C, T1486C | Brazil | H | md 29 | 86 | 230 | 74 | PCR–RFLP | Yes |
Sam-Agudu, 2010 [22] | TLR4-A299G, T399I TLR9-T1486C, T1237C | Uganda | H | 6.2 (2.4) | 63.1 | Cases (SM): 65 | Controls (UM: 52 | PCR and LDR-FMA | Yes |
Zakeri, 2011 [23] | TLR4 D299G, T399I TLR9 T1486C, T1237C | Iran | HCs | md 28 | 65.6 | P. falciparum infected: 320 | Healthy control: 320 | PCR–RFLP | Yes |
Esposito, 2012 [24] | TLR4 A299G (rs4986790) TLR9 T1486C (rs187084), T1237C (rs5743836) | Burundi | H | Children | 57.5 | 602 | 337 | Taqman | Yes |
Munde, 2012 [25] | TLR9 T1237C | Kenya | H | Children | 47.8 | SM: 138 | UM: 163 | TaqMan | Yes |
Sawian, 2012 [26] | TLR4 A299G TLR9 T1237C, T1486C | India | H | md: 26.2 (R2-58) |  | SM: 136 | Controls (UM: 53 | PCR–RFLP | No |
Kar, 2015 [27] | TLR4 D299G TLR9 T1237C, T1486C | India | H | SM: 38.0 (25.0–53.7) UM: 38.0 (24.2–55.0) | 58% | 200 | 200 | PCR–RFLP | Yes (D299G) No (T1237C and T1486C) |
Iwalokun, 2015 [28] | TLR4 A299G, T399I | Nigeria | H | Children | 62.1 | 182 | 97 | PCR–RFLP | Yes |
Costa, 2017 [29] | TLR4 A299G (rs4986790), T399I (rs4986791) TLR9-T1237C (rs187084), T1486C (rs5743836) | Brazil |  | 37 (19 ± 53) | 61.5 | Pv-325 | Healthy group: 274 | PCR–RFLP | Yes (A299G, T399I, T1237C) No (T1486C) |
Rani, 2018 [30] | TLR4 A299G | Pakistan | H | 22.7 ± 13.6 | 53.5 | 228 (SM: 89, UM: 139) | 226 | Allele-specific PCR | No |