Factors influencing phagocytosis of malaria parasites: the story so far

Malaria Journal

Table 1 Different sub-populations of phagocytes and their phagocytic ability in malaria

Phagocyte population	Surface marker expression	Origin	Phagocytic ability		References
Phagocyte population	Surface marker expression	Origin	Parasite species	Phagocytic ability	References
Monocytes
Classical monocytes	CD14^brightCD16⁻	Human	P. falciparum IEs	Intermediate/inflammatory > non-classical > classical	[5, 10]
Intermediate/inflammatory monocytes	CD14^brightCD16⁺
Non-classical monocytes	CD14^dimCD16⁺
Macrophages
Splenic macrophages	CD11b^highCD14⁺F4/80⁺TCRβ⁺	Mouse	P. berghei IEs	Higher phagocytic potential compared to TCRβ⁻ macrophages	[53]
Splenic macrophages	CD11b⁺Tim3⁺	Mouse	P. berghei IEs	Reduced phagocytic ability due to Tim3 expression	[55]
Neutrophils
TCRβ+ neutrophils	CD11b⁺ Ly6G⁺TCRβ+	Mouse	P. berghei IEs	Higher phagocytic potential compared to TCRβ⁻ neutrophils	[79]
Low density neutrophils	CD66b⁺CD16⁺CD11b⁺CD15⁺	Human	P. vivax-infected reticulocytes	Comparable phagocytic potential to high density neutrophils from malaria patients, higher phagocytosis ability compared to high density neutrophils from healthy donors	[76]

ISSN: 1475-2875