Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children

Table 1 Description of study participants

Characteristics	Malaria-Free controls (MFC) n = 200	Uncomplicated malaria (UM) n = 218	Severe malaria (SM) n = 182	P value Between Groups
Gender
Girls n = 321	104(52%)	115 (52.8%)	102 (56%)	0.704
Boys n = 279	96 (48%)	103 (47.2%)	80 (44%)	0.704
Age (mean ± SD)	4.0 ± 1.4	4.1 ± 1.4	4.1 ± 1.1	0.89
Parasite density (mean ± SD)	NA	6438.4 ± 990	15,911.4 ± 403	< 0.001
Temperature (mean ± SD)	36.9 ± 0.28	38.9 ± 0.72	41.1 ± 0.7	< 0.001
Malaria complication
Severe anaemia n (%)	NA	NA	56 (30.8%)	< 0.001
Cerebral malaria n (%)	NA	NA	61 (33.5%)
Other complication^a n (%)	NA	NA	65 (35.7%)

^aOther complication (hypoglycaemia, jaundice, pulmonary oedema and acute respiratory distress)

ISSN: 1475-2875