Intervention | Details |
---|---|
Insecticide-treated nets (ITNs) | Distributed annually on January 1st; |
Initial blocking 90%, decaying exponentially with a 2-year half-life; | |
Initial killing 60%, decaying exponentially with a 4-year half-life; | |
Nets are discarded with exponential decay and a 6-month half-life; | |
A randomly-selected 10% of the population never receives a net; | |
Everyone who owns a net uses it every night. | |
Indoor residual spraying (IRS) | Distributed annually on January 1st; |
Initial killing 60%, decaying exponentially with a 6-month half-life; | |
No correlation between IRS and ITN coverage. | |
Artemether-Lumefantrine (AL) case management | Constant throughout simulation; |
“Coverage” refers to the probability of seeking care given a clinical case; | |
Upon deciding to seek care, per-day probability of care-seeking is 0.15; | |
No age dependence; | |
Drugs clear infection and provide about two weeks of additional protection. | |
Dihydro-artemisinin-Piperaquine (DP) case management | Constant throughout simulation; |
Same as AL case management, but with 1 month of protection after use. | |
Pre-Erythrocytic vaccine (PEV) | Constant throughout simulation; |
90% acquisition blocking, decaying exponentially; | |
6- and 12- month decay half-lives; | |
Distributed to infants upon reaching 6 months of age. | |
Transmission-blocking vaccine (TBV) | Distributed annually on January 1st; |
90% transmission blocking, decaying exponentially; | |
6- and 12- month decay half-lives; | |
Distributed to adults age 15-49. | |
Attractive targeted sugar baits (ATSB) | Distributed twice per year on January 1st and July 1st; |
Reported in terms of per-feed mortality rate, not coverage; | |
6-month box duration of efficacy. | |
Monoclonal antibodies (mABs) | Distributed annually on January 1st; |
Simulated via a PEV (see parameters above); | |
Distributed to adults age 15-49; | |
3-month box duration of protection. |