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Table 4 Performance of rapid diagnostic tests for malaria diagnosis in Djibouti city, 2018–2021

From: Molecular investigation of malaria-infected patients in Djibouti city (2018–2021)

Performance

Year1

2018

2019

2020

2021

n

%

n

%

n

%

n

%

P. falciparum

        

True positive

55

71

27

14

62

22

174

47***

False positive

11

14

6

3

6

2

25

6.7*

True negative

12

15

85

45

76

26

111

29

False negative

0

0

69

37

144

50

64

17***

Total

78

100

187

100

288

100

374

100

Sensitivity

 

100

 

28.1

 

30.1

 

73.1***

Specificity

 

52.2

 

93.4

 

92.7

 

81.6*

PPV

 

83.3

 

81.8

 

91.2

 

87.7

NPV

 

100

 

55.2

 

34.6

 

63.4

Accuracy

 

85.9

 

59.9

 

47.9

 

76.5

P. vivax

        

True positive

9

12

27

14

23

8

23

6*

False positive

1

1

4

2

3

1

67

17.9***

True negative

62

79

147

79

254

88

272

73

False negative

6

8

9

5

8

3

12

3

Total

78

100

187

100

288

100

374

100

Sensitivity

 

60.0

 

75.0

 

74.2

 

65.7

Specificity

 

98.4

 

97.3

 

98.8

 

80.2***

PPV

 

90.0

 

87.1

 

92.0

 

51.1

NPV

 

98.4

 

94.2

 

98.4

 

97.1

Accuracy

 

97.3

 

93.0

 

97.9

 

90.8

  1. 1In 2018–2020, CareStart malaria Pf/Pv HRP2/pLDH RDT was used. In 2021, Biosynex malaria P.f/pan pLDH was used. P-values for the comparison between Biosynex2021 vs CareStart RDT2018-2020: < 0.01*, < 0.001**, < 0.0001***. PPV: Positive predictive value; NPV: Negative predictive value