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Table 3 Multivariable analysis of determinants of day 0 WBC count, by Plasmodium species

From: Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial Resistance Network individual patient data meta-analysis

 

Plasmodium falciparum n = 23132

Plasmodium vivax n = 2605

% change in day 0 WBC count1 (95% CI)

% change in day 0 WBC count1 (95% CI)

Age group

 < 1 year

21.7 (18.6, 24.7)

N/A

 1–4 years

Reference

Reference2

 5–14 years

− 16.5 (− 18.1, − 14.8)

− 11.9 (− 16.9, − 6.9)

 15 + years

− 31.7 (− 33.2, − 30.1)

− 17.4 (− 22.0, − 12.8)

 Log 10 Parasitaemia (/µL)

1.9 (1.1, 2.6)

5.7 (3.5, 8.0)

Anaemia 

 None

Reference

Reference

 Moderate

− 6.3 (− 7.4, − 5.2)

− 12.0 (− 15.8, − 8.3)

 Severe

− 8.5 (− 10.8, − 6.5)

− 36.4 (− 45.6, − 27.2)

Fever

 No

Reference

N/S

 Yes

4.1 (2.9, 5.4)

N/S

Relapse periodicity3

 Long

N/A

Reference

 Short

N/A

16.4 (6.9, 26.0)

  1. Comparisons with the reference group were significant at p < 0.001 for all variables
  2. 1% change in day 0 geometric mean of WBC count compared to the reference group
  3. 2 Includes 2 individuals < 1 year of age
  4. 3 P. vivax relapse periodicity, defined as: Short ≤ 47 days, Long > 47 days
  5. N/A Not applicable. N/S Not significant. WBC white blood cell
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Malaria Journal

ISSN: 1475-2875

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