Skip to main content
Fig. 4 | Malaria Journal

Fig. 4

From: Isoliensinine from Cissampelos pariera rhizomes exhibits potential gametocytocidal and anti-malarial activities against Plasmodium falciparum clinical isolates

Fig. 4

Target analyses formulating mode-of-action hypotheses. A Distribution of the 54 predicted target classes affected by isoliensinine. All the “active” labelled mammalian cellular targets predicted in the ChEMBL database at 70–90% confidence for isoliensinine (ID: ChEMBL502370) were recorded and their classes identified. The total number of each class is indicated in the brackets. B: Functional classification of the successfully identified Plasmodium homologs. Inset: Enriched target classes after homology searches in PlasmoDB. Protein sequences of the respective predicted targets retrieved from the UniProt database (using ChEMBL IDs) were used to query PlasmoDB using the BLASTp function. The returned orthologs based on identity score were functionally classified utilizing annotations at PlasmoDB and characterization results on published literature

Back to article page

Malaria Journal

ISSN: 1475-2875

Contact us