Does vitamin D reduce the mortality rate of Plasmodium infection?: a systematic review and meta-analysis

Malaria Journal

Table 1 Summary of studies reporting the relationship between vitamin D administration and mortality rate in experimental model for malaria

Author	No. case	No. control	Mice breed	Parasite species	No. Parasites	Type of intervention	Time of vitamin administration*	Type of vitamin D	Dose of vitamin (μg/kg)	Alive case (day 6)	Alive control (day 6)	Alive case (day 10)	Alive control (day 10)
Dwivedi et al. [9]	9	18	C57BL/6	P. berghei	3 × 10⁶	IM	After	1,25 (OH)₂ D3	50	8	15	3	0
He et al. [6]	28	40	C57BL/6	P. berghei	1 × 10⁶	Oral	Before	Cholecalciferol	50	28	36	28	12
He et al. [6]	23	40	C57BL/6	P. berghei	1 × 10⁶	Oral	After	Cholecalciferol	50	23	36	23	12
He et al. [6]	40	40	C57BL/6	P. berghei	1 × 10⁶	Oral	After	Cholecalciferol	50	40	36	40	12
He et al. [6]	10	10	C57BL/6	P. berghei	1 × 10⁶	IP	Before	Cholecalciferol	0.5	10	9	2	3
Waisberg et al. [5]	10	10	C57BL/6	P. berghei	1 × 10⁶	IP	Before	Cholecalciferol	0.5	6	5	0	0
Wu et al., 2018 [3]	10	10	C57BL/6	P. berghei	1 × 10⁶	Oral	Before	Cholecalciferol	50	10	9	10	2
Yamamoto et al. [14]	6	6	BALBC	P. chabaudi	141 × 10⁴	SC	After	1,25 (OH)₂ D3	3	5	6	2	1
Yamamoto et al. [14]	5	5	C57BL/6	P. chabaudi	141 × 10⁴	SC	NA	1,25 (OH)₂ D3	3	5	5	5	5
Yamamoto et al. [14]	5	5	C57BL/10	P. chabaudi	141 × 10⁴	SC	After	1,25 (OH)₂ D3	3	5	5	5	5
Yamamoto et al. [14]	5	5	IFNγ -/-	P. chabaudi	1 × 10⁴	SC	After	1,25 (OH)₂ D3	3	5	5	3	0
Yamamoto et al. [14]	5	5	IFNγ -/-	P. chabaudi	1 × 10⁴	SC	After	1,25 (OH)₂ D3	3	5	5	3	0
Yamamoto et al. [14]	5	5	VDR -/-	P. chabaudi	1 × 10⁴	SC	Before	1,25 (OH)₂ D3	3	5	5	5	5
Yamamoto et al. [8]	6	6	BALBC	P. chabaudi	141 × 10⁴	SC	After	1,25 (OH)₂ D3	0.6	6	6	6	2
Yamamoto et al. [8]	16	10	BALBC	P. chabaudi	141 × 10⁴	Oral	Before	1,25 (OH)₂ D3	0.6	16	8	10	5

ISSN: 1475-2875