Table 2 Sub-group analysis between vitamin D administration and mortality rate in experimental model of malaria (day 6)
Sub-group | No. studies | RR (CI 95%) | I2 | p-valuea |
|---|---|---|---|---|
Parasite species | ||||
P. berghei | 7 | 1.10 (1.04,1.17) | 0 | 0.999 |
P. chabaudi | 8 | 1.02 (0.90, 1.015) | 0 | 0.941 |
Mice breed | ||||
C57/BL6 | 8 | 1.10 (1.03, 1.17) | 0 | 0.999 |
Other | 7 | 1.02 (0.88, 1.16) | 0 | 0.891 |
Mice age in administration day | ||||
< 49 days | 6 | 1.10 (1.04, 1.17) | 0 | 0.999 |
> 60 days | 9 | 1.02 (0.91, 1.15) | 0 | 0.964 |
Number parasites | ||||
≤ 106 | 9 | 1.09 (1.03, 1.16) | 0 | 0.999 |
> 106 | 6 | 1.04 (0.90, 1.19) | 0 | 0.807 |
Dose of vitamin D | ||||
= 50 μg/kg | 5 | 1.10 (1.03,1.18) | 0 | 0.999 |
< 50 μg/kg | 10 | 1.04 (0.94, 1.15) | 0 | 0.994 |
Time of vitamin administration | ||||
Before infection | 6 | 1.11 (1.01, 1.22) | 0 | 0.967 |
After infection | 9 | 1.07 (1.10, 1.15) | 0 | 0.961 |
Type of intervention | ||||
Oral | 5 | 1.11 (1.04, 1.18) | 0 | 0.967 |
Injection | 10 | 1.02 (0.91, 1.13) | 0 | 0.998 |
Type of vitamin D | ||||
Cholecalciferol | 6 | 1.10 (1.03, 1.17) | 0 | 0.999 |
1,25 (OH)2 D3 | 9 | 1.02 (0.91, 1.14) | 0 | 0.967 |
All studies | 15 | 1.08 (1.03, 1.15) | 0 | 0.996 |