Table 3 Sub-group analysis between vitamin D administration and mortality rate in experimental model of malaria (day 10)
Sub-group | No. studies | RR (CI 95%) | I2 | p-valuea |
|---|---|---|---|---|
Parasite species | ||||
P. berghei | 7 | 3.15 (2.44, 4.07) | 0 | 0.521 |
P. chabaudi | 8 | 1.28 (0.92, 1.77 | 50.79 | 0.143 |
Mice breed | ||||
C57/BL6 | 8 | 2.36 (1.46, 3.83) | 72.13 | < 0.001 |
Other | 7 | 1.40 (0.95, 2.07) | 42.07 | 0.113 |
Mice age in administration day | ||||
< 49 days | 6 | 3.17 (2.45, 4.10) | 0 | 0.436 |
> 60 days | 9 | 1.23 (0.93, 1.63) | 35.60 | 0.207 |
Number parasites | ||||
≤ 106 | 9 | 2.40 (1.55, 3.73) | 64.66 | 0.001 |
> 106 | 6 | 1.39 (0.91, 2.11) | 56.01 | 0.095 |
Dose of vitamin D | ||||
≥ 50 μg/kg | 5 | 3.37 (2.55, 4.27) | 0 | 0.925 |
< 50 μg/kg | 10 | 1.19 (0.92, 1.54) | 27.67 | 0.254 |
Time of vitamin administration | ||||
Before infection | 6 | 1.83 (1.08, 3.14) | 67.27 | 0.001 |
After infection | 9 | 2.05 (1.30, 3.23) | 70.44 | < 0.001 |
Type of intervention | ||||
Oral | 5 | 3.01 (2.37, 3.82) | 0 | 0.612 |
Injection | 10 | 1.53 (0.82, 1.56) | 32.04 | 0.332 |
Type of vitamin D | ||||
Cholecalciferol | 6 | 3.11 (2.41, 4.03) | 0 | 0.448 |
1,25 (OH)2 D3 | 9 | 1.28 (0.95, 1.72) | 41.08 | 0.101 |
All studies | 15 | 1.94 (1.39, 2.71) | 0 | < 0.001 |