Table 1 Frequency distribution of Pfdhfr, Pfdhps, and PfK13 point mutations vs. wild-type in P. falciparum isolates from Libreville
Genes | Codon | Wild-type % (n) | Mutated % (n) |
|---|---|---|---|
dhfr (N = 68) | S108N | 11.76 (8) | 88.24 (60) |
N51I | 14.71 (10) | 85.29 (58) | |
C59R | 20.59 (14) | 79.41 (54) | |
I164L | 97.06 (66) | 2.94 (2) | |
dhps (N = 65) | S436 (A/F) | 84.62 (55) | 15.38 (10) |
A437G | 4.62 (3) | 93.38 (62) | |
K540E | 100 (65) | 0 (0) | |
A581G | 100 (65) | 0 (0) | |
A613S | 100 (65) | 0 (0) | |
k13 (N = 58) | Y493H | 100 (58) | 0 (0) |
R539T | 100 (58) | 0 (0) | |
I543T | 100 (58) | 0 (0) | |
A578S | 100 (58) | 0 (0) | |
C580Y | 100 (58) | 0 (0) | |
V589I | 100 (58) | 0 (0) | |
E/G 605Â K | 100 (58) | 0 (0) |