Table 2 Frequency of haplotypes of Pfdhfr, Pfdhps, and combined Pfdhfr–Pfdhps in P. falciparum isolates
Gene | Types | Haplotype | Frequencya (n) |
|---|---|---|---|
Pfdhfr (N = 68) | Wild | NCSI | 7.35 (5) |
| Â | Single mutation | ICSI | 1.47 (1) |
| Â | Â | NCNI | 5.88 (4) |
| Â | Double mutation | IRSI | 1.47 (1) |
| Â | Â | ICNI | 4.41 (3) |
| Â | Â | ICNL | 1.47 (1) |
| Â | Triple mutation | IRNI | 76.48 (52) |
| Â | Â | NRNL | 1.47 (1) |
Pfdhps (N = 65) | Wild | SASKAA | 0 (0) |
| Â | Single mutation | AAKAA | 4.62 (3) |
| Â | Â | SGKAA | 84.62 (55) |
| Â | Double mutation | (A/F)GKAA | 10.76 (7) |
Pfdhfr – Pfdhps (N = 63) | Wild | NCSI–SASKAA | 0 (0) |
|  | Single mutation | NCSI–SGKAA | 6.35 (4) |
|  | Double mutation | ICSI–SGKAA | 1.59 (1) |
|  |  | NCNI–SGKAA | 4.76 (3) |
|  |  | NCSI–FGKAA | 1.59 (1) |
|  | Triple mutation | NCNI–FGKAA | 1.59 (1) |
|  |  | ICNI–SGKAA | 3.17 (2) |
|  |  | ICSL–SGKAA | 1.59 (1) |
|  |  | IRSI–SGKAA | 1.59 (1) |
|  | Quadruple mutation | IRNI–SGKAA | 63.49 (40) |
|  |  | IRNI–AAKAA | 4.76 (3) |
|  |  | NRNL–SGKAA | 1.59 (1) |
|  | Quintuple mutation | IRNI–AGKAA | 3.17 (2) |
|  |  | IRNI–FGKAA | 4.76 (3) |