Table 5 Composition of haplotypes of pvmdr1 gene CDSs from P. vivax strains in 2014 and 2020–2022
OD | Folds | Haplotype example | Fold loci composition of example | Types of the same folds | Total (n = 624) | Different between years | |||
|---|---|---|---|---|---|---|---|---|---|
2014 (n = 283) | 2020 (n = 140) | 2021 (n = 119) | 2022 (n = 82) | ||||||
1 | 3 | Hap_87, et al. | G698S/M908L/T958M, et al. | 1 | 1 (0.2%) | 1 (0.4%) | 0 | 0 | 0 |
2 | 4 | Hap_8, et al. | G698S/M908L/T958M/S1358S, et al. | 5 | 27 (2.7%) | 26 (9.2%) | 1 (0.7%) | 0 | 0 |
3 | 5 | Hap_40, et al. | T529T/ G698S /M908L/T958M /F1076L, et al. | 13 | 122 (19.6%) | 45 (15.9%) | 33 (23.6%) | 24 (20.2%) | 19 (23.2%) |
4 | 6 | Hap_91, et al. | P8L/L310L/T529T/M908L/T958M/F1076L, et al. | 32 | 187 (30.0%) | 79 (28.0%) | 47 (33.6%) | 38 (31.9%) | 24 (29.3%) |
5 | 7 | Hap_24, et al. | K44K/T529T/G698S/M908L/T958M/F1076L/S1450L, et al. | 33 | 227 (36.4%) | 85 (30.0%) | 52 (37.1%) | 54 (45.4%) | 36 (43.9%) |
6 | 8 | Hap_5, et al. | L493L/T529T/G698S/L845F/M908L/T958M/F1076L/E1233E, et al. | 12 | 18 (2.9%) | 16 (5.7%) | 0 | 0 | 2 (2.4%) |
7 | 9 | Hap_3, et al. | K44K/T529T/G698S/L845F/M908L/T958M/F1076L/L1120L/S1450L, et al. | 7 | 18 (2.9%) | 17 (6.0%) | 0 | 1 (0.8%) | 0 |
8 | 10 | Hap_14, et al. | K44K/G520D/T529T/G698S/A861E/M908L/T958M/F1076L/I1348I/S1450L, et al. | 2 | 24 (3.8%) | 14 (4.9%) | 7 (5.0%) | 2 (1.7%) | 1 (1.2%) |