Fig. 3
From: Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes
Screening for ivermectin metabolites effect on mosquito mortality. Anopheles stephensi mosquitoes were treated with blank human blood, blood containing ivermectin (IVM, 50 ng/mL), or ivermectin metabolite (M1-M9). Data represent three independent replicates per compound, each containing an average of 28 mosquitoes/condition. A Mortality over time. Mean mosquito survival was assessed after 24 h, 48 h and 72 h. Error bars correspond to the standard error or the mean. B Percent survivorship of An. stephensi 72 h; after feeding on ivermectin or its metabolites (M1–M9). Significant differences in the means of two groups are marked, *** shows a p-value < 0.001 with a t-test