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Table 3 Reactive case detection (RACD) versus reactive drug administration (RDA) intervention studies (n = 2)

From: Testing and treatment for malaria elimination: a systematic review

Study

Country

Trans-mission

Species

Design

Total no. clusters

Total population

Test

Drug regimen

      

Outcome

RACD as control

RDA Intervention

RDA + RAVC Intervention

Prevalence of infection

Incidence of symptomatic cases

No. of events

Coverage of events

No. of events

Coverage of events

No. of events

Coverage of events

Follow up (months)

RDA vs RACD

PR, 95% CI

RDA + RAVC vs RACD

PR, 95% CI

Follow up (months)

RDA vs RACD

IRR, 95% CI

RDA + RAVC vs RACD

IRR, 95% CI

Ntuku et al. 2020

Namibia

Low

Pf

CRCT

56

5–20K

RDT

AL

178

84%

164

91%

144

89%

8

0·59 (0·21–0·98)

0·16 (0·05–0·55)

12

0·52 (0·16–0·88)

0·26 (0·10–0·68)

Vilakati et al. 2021

Eswatini

Very low

Pf

CRCT

77

> 50K

RDT

DP

46

70%

64

62%

–

–

–

–

–

24

0.84 (0.42 to 1.66)

–

  1. RACD reactive case detection, RDA reactive drug administration; RAVC reactive vector control (indoor residual spraying using pirimiphosmethyl)
  2. Prevalence assessed in all ages and using PCR
  3. Incidence of symptomatic local cases assessed in all ages through passive case detection