A field bioassay for assessing ivermectin bio-efficacy in wild malaria vectors

Malaria Journal

Table 1 Comparison of An. gambiae s.s. survival post feeding on different IVM concentrations spiked in glucose solution (A) or blood (B)

A. Ivermectin bio-efficacy in 10% glucose solution
Treatment	N	n	HR	95% CI	p-value
IVM 85 ng/ml	3	155	2.46	1.86–3.31	< 0.001
IVM 64 ng/ml	3	150	1.68	1.24–2.26	< 0.001
IVM 43 ng/ml	3	151	1.35	1.00–1.82	0.054
IVM 21 ng/ml	3	150	1.26	0.93–1.70	0.140
No IVM—Control	3	147	1	–	–

B. Ivermectin bio-efficacy in blood
Treatment	N	n	HR	95% CI	p-value
IVM 85 ng/ml	3	134	28.02	17.19–45.65	< 0.001
IVM 64 ng/ml	3	132	24.27	14.89–39.56	< 0.001
IVM 43 ng/ml	3	133	22.98	14.09–37.48	< 0.001
IVM 21 ng/ml	3	139	7.77	4.73–12.75	< 0.001
No IVM—Control	3	144	1	–	–

N number of replicates, n total number of mosquitoes, HR hazard ratios, CI confidence intervals
Log rank test comparing survival of An. gambiae s.s. mosquitoes after feeding on different IVM concentrations spiked in glucose solution (A) or blood (B)

ISSN: 1475-2875