Table 2 An. gambiae s.s. survival post feeding on different IVM concentrations spiked in glucose solution mixed with blood in different proportions 1:1 (A), 1:2 (B), 1:4 (C), and 1:8 (D)
From: A field bioassay for assessing ivermectin bio-efficacy in wild malaria vectors
A. Ivermectin bio-efficacy in 1:1 (Blood: Glucose solution) | |||||
|---|---|---|---|---|---|
Treatment | N | n | HR | 95% CI | p-value |
IVM 85 ng/ml | 3 | 139 | 12.99 | 8.64–19.53 | < 0.001 |
IVM 64 ng/ml | 3 | 149 | 10.49 | 6.99–15.75 | < 0.001 |
IVM 43 ng/ml | 3 | 143 | 7.44 | 4.94–11.20 | < 0.001 |
IVM 21 ng/ml | 3 | 143 | 4.79 | 3.16–7.26 | < 0.001 |
No IVM—Control | 3 | 150 | 1 | – | – |
B. Ivermectin bio-efficacy in 1: 2 (Blood: Glucose solution) | |||||
|---|---|---|---|---|---|
Treatment | N | n | HR | 95% CI | p-value |
IVM 85 ng/ml | 3 | 133 | 9.37 | 6.43–13.65 | < 0.001 |
IVM 64 ng/ml | 3 | 145 | 5.35 | 3.67–7.79 | < 0.001 |
IVM 43 ng/ml | 3 | 137 | 5.16 | 3.53–7.53 | < 0.001 |
IVM 21 ng/ml | 3 | 145 | 3.76 | 2.57–5.51 | < 0.001 |
No IVM—Control | 3 | 127 | 1 | – | – |
C. Ivermectin bio-efficacy in 1: 4 (Blood: Glucose solution) | |||||
|---|---|---|---|---|---|
Treatment | N | n | HR | 95% CI | p-value |
IVM 85 ng/ml | 3 | 150 | 6.42 | 4.57–9.01 | < 0.001 |
IVM 64 ng/ml | 3 | 157 | 6.83 | 4.88–9.55 | < 0.001 |
IVM 43 ng/ml | 3 | 156 | 6.41 | 4.58–8.98 | < 0.001 |
IVM 21 ng/ml | 3 | 150 | 4.32 | 3.07–6.08 | < 0.001 |
No IVM—Control | 3 | 150 | 1 | – | – |
D. Ivermectin bio-efficacy in 1: 8 (Blood: Glucose solution) | |||||
|---|---|---|---|---|---|
Treatment | N | n | HR | 95% CI | p-value |
IVM 85 ng/ml | 3 | 147 | 6.48 | 3.93–10.70 | < 0.001 |
IVM 64 ng/ml | 3 | 148 | 6.06 | 3.67–10.02 | < 0.001 |
IVM 43 ng/ml | 3 | 148 | 3.60 | 2.14–6.06 | < 0.001 |
IVM 21 ng/ml | 3 | 150 | 3.04 | 1.80–5.14 | < 0.001 |
No IVM—Control | 3 | 149 | 1 | – | – |