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Table 3 Comparison of mosquitocidal effects of high, middle, and low IVM concentrations administered in blood alone and blood-glucose mixtures of varying ratios

From: A field bioassay for assessing ivermectin bio-efficacy in wild malaria vectors

Treatment

N

Outcome

OR 95% CI

p-Value

  

n1

n2

n3

  

85 ng/ml

 Experiments

      

 Blood

3

134

122

12

Ref

 

 Glucose

3

155

76

79

0.09 (0.05, 0.19)

< 0.001

 BS 1:1

3

139

112

27

0.41 (0.20, 0.84)

0.016

 BS 1:2

3

133

115

18

0.63 (0.29, 1.36)

0.239

 BS 1:4

3

150

118

32

0.36 (0.18, 0.74)

0.005

 BS 1:8

3

147

61

86

0.07 (0.04, 0.14)

< 0.001

43 ng/ml

 Blood

3

133

118

15

Ref

 

 Glucose

3

151

36

115

0.04 (0.02, 0.08)

 < 0.001

 BS 1:1

3

143

78

65

0.15 (0.08, 0.29)

< 0.001

 BS 1:2

3

137

80

57

0.18 (0.09, 0.34)

< 0.001

 BS 1:4

3

156

129

27

0.61 (0.31, 1.20)

0.15

 BS 1:8

3

148

31

117

0.03 (0.02, 0.07)

< 0.001

21 ng/ml

 Blood

3

139

75

64

Ref

 

 Glucose

3

150

20

130

0.13 (0.07, 0.28)

< 0.001

 BS 1:1

3

143

48

95

0.43 (0.27, 0.70)

< 0.001

 BS 1:2

3

145

69

76

0.77 (0.49, 1.24)

0.283

 BS 1:4

3

150

104

46

1.93 (1.19, 3.12)

0.007

 BS 1:8

3

150

22

128

0.15 (0.08, 0.26)

< 0.001

  1. n1-Total exposed, n2-Total dead, n3-Total alive. Outcome-Survival of mosquitoes within the first 14 days of survival time in each experiment
  2. Ref Reference category (Blood), OR odds ratio, CI confidence interval