Fig. 6

Combination experiment with humAbs 065098 and DB10: A Growth inhibition curves for humAbs DB10 and 065098 individually and in combination. One antibody was varied in a two-fold dose response at eight concentrations while the other was held constant at 50 µg/mL, and then inversely (red and violet curves); individual curves for DB10 (dashed blue curve) and 065098 (dashed green curve) are overlaid for comparison, data referenced from Figs. 2 and 3. All points represent mean and standard deviation with triplicate cultures. B 3-D dose–response matrices showing the concentrations of 065098 on the x-axis, DB10 on the y-axis, and synergy score (δ) on the z-axis. Refer to legend in Fig. 3 describing Bliss synergy matrix and scores