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Table 4 Effect of interventions on prevalence (%) of malaria-helminth co-infection among study participants, Saraya, 2022

From: Feasibility and safety of integrating mass drug administration for helminth control with seasonal malaria chemoprevention among Senegalese children: a randomized controlled, observer-blind trial

 

Pre-intervention

Prevalence 95% CI

Post-intervention

Prevalence 95% CI

Odds ratio

OR 95% CI

Odds ratio

OR 95% CI

P value*

P value**

 

Control group

Treatment Group 1

Treatment Group 2

Control Group

Treatment Group 1

Treatment Group 2

Treatment Group 1 vs control group, Post-intervention

Treatment Group 2 vs control group, Post-intervention

  

Plasmodium spp

 P. falciparum

8.4 (5.4–13.0)

7.7 (4.8–12.3)

6.8 (4.1–11.2)

8.9 (5.7–13.5)

12.1 (8.3–17.3)

11.2 (7.5–16.3)

1.45 (0.72–2.91)

1.24 (0.60–2.54)

0.58

0.33

 ***P. malariae

8.4 (5.4–13.0)

6.8 (4.0–11.1)

6.3 (3.7–10.6)

8.4 (5.4–13.0)

11.6 (7.9–16.7)

10.7 (7.1–15.7)

1.45 (0.71–2.96)

1.24 (0.59–2.57)

0.59

0.22

Schistosomiasis

 S. haematobium

0.5 (0.07–3.7)

1.1 (0.3–4.5)

(0.3–4.4)

0.5 (0.08–3.8)

1.2 (0.3–4.6)

1.1 (0.3–4.3)

 

 ***S. mansoni

0.5 (0.07–3.7)

1.1 (0.3–4.5)

1.1 (0.3–4.5)

0.5 (0.08–3.8)

1.2 (0.3–4.6)

1.1 (0.3–4.3)

    

STH

 ***Hookworm

0

0

1.1 (0.3–4.4)

0.6 (0.08–3.8)

0.6 (0.08–4.1)

0

 

 ***A. lumbricoides

          

 ***T. trichiura

          

 Intestinal protozoans

62.6 (55.4–69.2)

56.1 (48.6–63.3)

58.9 (51.3–65.8)

60.0 (52.6–66.9)

65.9 (58.4–72.6)

66.4 (59.2–73.0)

1.25 (0.78–2.01)

1.37 (0.86–2.19)

0.40

0.30

Co-infection

 Plasmodium + intestinal protozoans

4.8 (2.5–9.0)

5.2 (2.7–9.7)

4.0 (1.9–8.1)

5.6 (3.0–10.0)

10.0 (6.3–15.5)

10.6 (6.9–16.1)

1.96 (0.79–4.82)

1.95 (0.79–4.78)

0.26

Hb (g/dl)

          

 (severe anaemia vs moderate/mild/

normal)

0

0

0

1.5 (0.5–4.7)

1.1 (0.3–4.3)

2.1 (0.8–5.5)

0.81 (0.13–5.00)

1.78 (0.38–8.27)

0.63

0.83

  1. *Wald test assessing evidence of difference in post-randomization prevalence between trial arms, after controlling for pre-randomization occurrence of outcome and baseline characteristics (sex, age group, weight, and other infections’ occurrence). ** Effect modification test between intervention period and trial arm. ***Number very low to enable statistical comparisons