Table 2 Frequency and distribution of Pfk13 propeller domain haplotypes in samples from Kenya and Ethiopia, 2018-2022
| Â | Kenya, n (%) | Ethiopia, n (%) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Haplotypes | Mutation | Type†| Homa Bay (N = 466) | Kakamega (N = 126) | Kombewa (N = 179) | Kisii (N = 12) | Arjo (N = 91) | Awash (N = 23) | Dire Dawa (N = 50) | Gambella (N = 133) | Semera (N = 22) |
Hap_1 | Wildtype | – | 453 (97.21%) | 105 (83.33%) | 171 (95.53%) | 12 (100%) | 90 (98.90%) | 23 (100.00%) | 49 (98.00%) | 133 (100.00%) | 19 (82.61%) |
Hap_2 | A582V (1745C > T) | NS | 2 (0.43)% | 7 (5.56%) | 1 (0.56%) | 0 | 1 (1.10%) | 0 | 0 | 0 | 0 |
Hap_3 | V637V (1911 T > A) | S | 3 (0.64%) | 1 (0.79%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hap_4 | G690G (2070C > G) | S | 1 (0.21%) | 0 | 2 (1.12%) | 0 | 0 | 0 | 0 | 0 | 0 |
Hap_5 | G533G (1599G > A) | S | 2 (0.43)% | 0 | 2 (1.12%) | 0 | 0 | 0 | 0 | 0 | 0 |
Hap_6 | H560H (1680 T > C) | S | 1 (0.21%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hap_7 | P655P (1965A > T) | S | 0 | 0 | 1 (0.56%) | 0 | 0 | 0 | 0 | 0 | 0 |
Hap_8 | A675V (2024C > T) | NS | 0 | 3 (2.38%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hap_9 | P667S (1999C > T) | NS | 0 | 1 (0.79%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hap_10 | A578S (1732G > T) | NS | 3 (0.64%) | 6 (4.76%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hap_11 | A569S (1705G > T) | NS | 0 | 1 (0.79%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hap_12 | I646L (1936A > T) | NS | 0 | 0 | 1 (0.56%) | 0 | 0 | 0 | 0 | 0 | 0 |
Hap_13 | C469C (1407C > T) | S | 0 | 2 (1.59%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hap_14 | T535T (1605G > A) | S | 0 | 0 | 1 (0.56%) | 0 | 0 | 0 | 0 | 0 | 0 |
Hap_15 | E643E (1929A > G) | S | 1 (0.21%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hap_16 | R622I (1865G > T) | NS | 0 | 0 | 0 | 0 | 0 | 0 | 1 (2.00%) | 0 | 3 (13.04%) |