Baseline | Intervention | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Arms | Cluster | n | Wild-type | Mutant | Frequency of R allele | n | Wild-type | Mutant | Frequency of R allele | ||||||||
SS | L1014F | L1014S | Hetero duplex | SS | L1014F | L1014S | Hetero duplex | ||||||||||
RS | RR | RS | RR | RS | RR | RS | RR | ||||||||||
Treated | 01 | 64 | 55 | 3 | 3 | 2 | – | 1 | 0.102 | 130 | 101 | 5 | 8 | 8 | 2 | 6 | 0.173 |
15 | – | – | – | – | – | – | – | #NA | 4 | 4 | – | – | – | – | – | 0.000 | |
16 | 107 | 107 | – | – | – | – | – | 0.000 | 717 | 651 | 37 | 18 | 8 | 1 | 2 | 0.061 | |
17 | 18 | 16 | – | – | 2 | – | – | 0.056 | 114 | 100 | 4 | 4 | 2 | 2 | 2 | 0.096 | |
19 | 91 | 82 | 5 | – | 1 | 3 | – | 0.066 | 196 | 187 | 6 | 2 | – | 1 | – | 0.031 | |
20 | 143 | 137 | 6 | – | – | – | – | 0.021 | 225 | 202 | 8 | 8 | 5 | 2 | – | 0.073 | |
Placebo | 02 | 312 | 253 | 19 | 21 | 16 | 1 | 2 | 0.133 | 854 | 551 | 65 | 131 | 39 | 28 | 40 | 0.294 |
03 | 20 | 20 | – | – | – | – | – | 0.000 | 87 | 85 | – | 1 | 1 | – | – | 0.017 | |
09 | 14 | 14 | – | – | – | – | – | 0.000 | 46 | 44 | – | – | – | – | 2 | 0.043 | |
21 | 63 | 62 | 1 | – | – | – | – | 0.008 | 74 | 69 | 3 | 2 | – | – | – | 0.047 | |
23 | 18 | 13 | 1 | – | 2 | – | 2 | 0.194 | 87 | 65 | 7 | 2 | 7 | 3 | 3 | 0.172 | |
24 | 40 | 40 | – | – | – | – | – | 0.000 | 96 | 82 | 3 | 6 | 2 | 1 | 2 | 0.120 | |
Total | 890 | 799 | 35 | 24 | 23 | 4 | 5 | 0.070 | 2630 | 2141 | 138 | 182 | 72 | 40 | 57 | 0.146 |