Table 1 Admission demographic, clinical information, and outcomes of children with cerebral malaria
Demographic or laboratory measure | Survived without neurologic sequelae (N = 1250) | Survived with neurologic sequalae (N = 152) | Died (N = 272) | P value for difference (died vs. survived) | P value for difference (in survivors, normal vs. neurologic sequelae) |
|---|---|---|---|---|---|
Age, months, mean (SD) | 47.2 (29.8) | 42.0 (26.5) | 44.7 (27.3) | 0.463 | 0.037 |
Sex, N (%) | |||||
Male | 605 (48%) | 75 (49.3%) | 120 (44.4%) | 0.218 | 0.833 |
Female | 644 (52%) | 77 (50.7%) | 150 (55.6%) | ||
Blantyre Coma Scale at admission, N (%) | |||||
0 | 124 (9.9%) | 25 (16.5%) | 69 (25.3%) | < 0.001 | < 0.001 |
1 | 480 (38.4%) | 77 (50.7%) | 122 (44.9%) | ||
2 | 646 (51.7%) | 50 (32.9%) | 81 (29.8%) | ||
Coma duration (hours), mean (SD) | 12.3 (15.8) | 13.9 (16.1) | 11.0 (11.9) | 0.990 | 0.008 |
Parasite count, mean (SD), log (10) | 4.5 (1.2) | 4.5 (1.1) | 4.7 (1.1) | 0.003 | 0.925 |
Haematocrit %, mean (SD) | 22.4 (7.2) | 23.7 (8.6) | 22.6 (8.4) | 0.858 | 0.165 |
Severe malarial anaemia (Hct < 15%), N (%) | 180 (14.5%) | 20 (13.5%) | 50 (18.5%) | 0.087 | 0.737 |
White blood cell count, mean (SD) | 11.0 (8.0) | 12.5 (6.7) | 15.0 (11.3) | < 0.001 | < 0.001 |
Lactate (mmol/L), mean (SD) | 6.3 (4.4) | 6.6 (4.6) | 9.2 (4.9) | < 0.001 | 0.534 |
Hyperlactataemia, N (%) | 496 (49%) | 61 (52%) | 162 (78%) | < 0.001 | 0.555 |
Glucose (mmol/L), mean (SD) | 6.6 (3.4) | 6.7 (4.3) | 6.7 (4.9) | 0.179 | 0.483 |
Received blood transfusion, N (%) | 445 (36%) | 55 (36%) | 92 (34%) | 0.561 | 0.887 |
Received > 1 blood transfusion | 25 (2%) | 5 (3%) | 18 (7%) | < 0.001 | 0.300 |
Received crystalloid bolus, N (%) | 153 (12%) | 25 (16%) | 81 (30%) | < 0.001 | 0.141 |
Received > 1 bolus | 25 (2.0%) | 5 (3.3%) | 18 (6.6%) | < 0.001 | 0.300 |