Post hospital admission blood lactate measurements are associated with mortality but not neurologic morbidity in children with cerebral malaria

Table 4 Incidence of hyperlactataemia in the first 24 h of hospital admission among children with cerebral malaria

Time (hours)	N at beginning of time interval^a	Deaths before next time point	Hyperlactataemia (n)	Number of those with hyperlactataemia without previous episodes of hyperlactataemia	Mortality rate of those with hyperlactataemia (%)	Mortality rate of those without hyperlactataemia (%)	p-value	Morbidity rate of those with hyperlactataemia (%)
0 (admit)	1336	61	717	NA	22	8	< 0.001	49
6	1043	28	286	67	22	9	< 0.001	25
12	977	17	142	21	22	8	< 0.001	13
18	929	23	119	24	22	6	< 0.01	10
24	864	25	112	30	12^b	6	0.022	10

^aParticipants at the beginning of time interval are those who were alive and had lactate measurements recorded at that time point
^bAt 24 h post-admission, the mortality rate of those with elevated blood lactate falls below the mortality fate of the overall cerebral malaria cohort

ISSN: 1475-2875