In-vitro susceptibility and ex-vivo evaluation of macrocyclic lactone endectocides sub-lethal concentrations against Plasmodium vivax oocyst development in Anopheles arabiensis

Table 1 Ivermectin, doramectin, moxidectin LC₅₀, LC₂₅ and LC₅ after Hemotek® membrane feeding of animal blood reconstituted with different dose or concentration (in ng/mL)) of ivermectin, doramectin and moxidectin

Sub-lethal concentrations	Ivermectin	Doramectin	Moxidectin
LC₅₀	40.7[36.4–45.8]	91.2[81.4–102.8]	5128.6[4625.6–9790.3]
LC₂₅	7.1[6.3–8.0]	20.0[17.8–22.5]	794.3[716.4–1516.3]
LC₅	0.6[0.5- 0.7]	1.8[1.6–2.0]	53.7[48.4–102.5]

Key: The number in bracket indicates the 95% CI; LC₅₀, LC₂₅ and LC₅, corresponds to the concentrations that kill 50%, 25% and 5% of the mosquitoes respectively

ISSN: 1475-2875