A quasi-experimental study to estimate effectiveness of seasonal malaria chemoprevention in Aweil South County in Northern Bahr El Ghazal, South Sudan

Khan, Jamshed; Suau Sans, Maria; Okot, Francis; Rom Ayuiel, Abubaker; Magoola, Jonathan; Rassi, Christian; Huang, Sikai; Mubiru, Denis; Bonnington, Craig; Baker, Kevin; Ahmed, Julla; Nnaji, Chuks; Richardson, Sol

doi:10.1186/s12936-024-04853-x

Table 3 Results of regression models for associations between SMC and caregiver-reported malaria outcomes among children aged 3–59 months using difference-in-differences analysis comparing Aweil South and Aweil West counties, June–November 2022

From: A quasi-experimental study to estimate effectiveness of seasonal malaria chemoprevention in Aweil South County in Northern Bahr El Ghazal, South Sudan

Outcome	Model description	Variable	Category	Odds ratio	95% CI	p
Caregiver-reported fever outcomes	Model 1: unadjusted model	County	Aweil South (intervention)	0.27	0.10–0.70	0.008
		Wave	Wave 2	2.78	1.77–4.37	< 0.001
		Wave	Wave 3	1.44	0.77–2.67	0.246
		Interaction	County*Wave 2	0.29	0.12–0.70	0.007
		Interaction	County*Wave 3	0.56	0.20–1.54	0.252
	Model 2: adjusted for child age and sex	County	Aweil South (intervention)	0.26	0.11–0.62	0.004
		Wave	Wave 2	2.60	1.68–4.04	< 0.001
		Wave	Wave 3	1.39	0.72–2.66	0.315
		Interaction	County*Wave 2	0.29	0.12–0.70	0.007
		Interaction	County*Wave 3	0.59	0.22–1.59	0.285
	Model 3: full model	County	Aweil South (intervention)	0.18	0.11–0.62	< 0.001
		Wave	Wave 2	2.40	1.68–4.04	0.001
		Wave	Wave 3	1.36	0.72–2.66	0.260
		Interaction	County*Wave 2	0.30	0.12–0.70	0.003
		Interaction	County*Wave 3	0.63	0.22–1.59	0.306
Caregiver-reported RDT-confirmed malaria outcomes	Model 1: unadjusted model	County	Aweil South (intervention)	1.10	0.51–2.23	0.807
		Wave	Wave 2	3.61	1.93–6.77	< 0.001
		Wave	Wave 3	3.32	1.91–5.76	< 0.001
		Interaction	County*Wave 2	0.21	0.08–0.55	0.003
		Interaction	County*Wave 3	0.21	0.06–0.62	0.006
	Model 2: adjusted for child age and sex	County	Aweil South (intervention)	1.10	0.51–2.38	0.803
		Wave	Wave 2	3.61	2.03–6.43	< 0.001
		Wave	Wave 3	3.31	1.91–5.73	< 0.001
		Interaction	County*Wave 2	0.20	0.08–0.54	0.002
		Interaction	County*Wave 3	0.21	0.07–0.63	0.006
	Model 3: full model	County	Aweil South (intervention)	0.94	0.45–1.93	0.860
		Wave	Wave 2	3.39	1.79–6.43	< 0.001
		Wave	Wave 3	3.39	1.89–6.08	< 0.001
		Interaction	County*Wave 2	0.18	0.07–0.49	0.001
		Interaction	County*Wave 3	0.18	0.06–0.54	0.003

Bold values indicate that the strength of evidence is significant at p<0.05

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