Fig. 1

Schematic view of a Plasmodium falciparum nucleosome organization. DNA is wrapped up around nucleosome, a histone core octamer structure, made of two H2A-H2B dimers bound to an H3-H4 tetramer [12]. Histone tails and in particular lysine and arginine residues, on which several post-translational modifications can occur, are generally positively charged allowing strong binding to DNA which possesses negatively charged phosphate groups