Table 1 Histone writers and erasers enzymes in P. falciparum
From: Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum
Name | PlasmoDB ID | Inferred/Known activity |
|---|---|---|
Histone acetyltransferases (HATs) | ||
PfGCN5 [72] | PF3D7_0823300 | H3K9, H3K14 acetylation |
PfMYST [75] | PF3D7_1118600 | H4K5, K8, K12, K16 acetylation |
PfHAT1 [71] | PF3D7_0416400 | Unknown |
PfELP3 [71] | PF3D7_1227800 | Unknown |
Histone deacetylases (HDACs) | ||
PfHDAC1 (Class I) [81] | PF3D7_0925700 | Parasite’s progression through intraerythrocytic developmental cycle |
PfHDA2 (Class II) [45] | PF3D7_1008000 | H3K9 deacetylation involved in gametocyte commitment, virulence gene silencer |
PfHDA1 (Class II) [82] | PF3D7_1472200 | Putative HDAC |
PF3D7_1328800 | Telomere maintenance and var gene silencing | |
PF3D7_1451400 | Silencing of var genes | |
PfSET1 | PF3D7_0629700 | H3K4 methylation |
PfSET2 | PF3D7_1322100 | H3K36 methylation |
PfSET3 | PF3D7_0827800 | H3K9 methylation |
PfSET4 | PF3D7_0910000 | H3K36 methylation |
PfSET5 | PF3D7_1214200 | Unknown |
PfSET6 | PF3D7_1355300 | H3K36 methylation |
PfSET7 | PF3D7_1115200 | H3K36, H3K9, H3K4 methylation |
PfSET8 | PF3D7_0403900 | H4K20 methylation |
PfSET9 | PF3D7_0508100 | H3K36 methylation |
PfSET10 | PF3D7_1221000 | H3K4 methylation |
PfPRMT1 | PF3D7_1426200 | H4R3 methylation |
LSD1 family | ||
PfLSD1 | PF3D7_1211600 | H3K4me1 and me2 demethylation |
PfLSD2 | PF3D7_0801900 | H3K4me1 and me2 demethylation |
Jumonji-related family | ||
PfJmjC1 | PF3D7_0809900 | Histone Lysine Demethylase |
PfJmjC2 | PF3D7_0602800 | Histone Lysine Demethylase |
PfJmjC3 | PF3D7_1122200 | Histone Lysine Demethylase |
PfDNMT2 | PF3D7_0727300 | DNA and tRNA methylation |