Table 2 Histone acetyltransferases (HAT) inhibitors in P. falciparum
From: Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum
Inhibitors | Structure | P. falciparum IC50 in µM | Specificity | CC50 on mammalian cells in µM (Cell type) |
|---|---|---|---|---|
Anacardic Acid |
| 30 [115] | Targets lipoxygenase activity [116] | > 100 (HeLa) [145] |
Curcumin |
| 25 [97] | No specificity, targets all HATs and involved in production of ROS [97] | 4 (HL60) [146] |
Embelin |
| 10 [73] | Specific towards GCN5 | > 40 (mammalian) [73] |
CB3717 |
| 0.225; 1 [117] | Specific towards PfGCN5 | > 20 (NIH3T3) [117] |
NU9056 |
| 0.9 [118] | Specific towards PfMyst | - |
