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Fig. 4 | Malaria Journal

Fig. 4

From: Classification and clinical significance of immunogenic cell death-related genes in Plasmodium falciparum infection determined by integrated bioinformatics analysis and machine learning

Fig. 4

Functional enrichment of DEGs between the two ICD subtypes using the clusterProfiler package. A Hallmark GSEA of 910 DEGs between the ICD subtype 1 and ICD subtype 2 groups. B KEGG GSEA of DEGs between the ICD subtype 1 and ICD subtype 2 groups. For A and B, “Gene ratio”is the proportion of genes from a predefined gene set that appear in the ranked list of genes being analysed. The size of the dots represents -log10 of the P-adjusted values, and the colour of the dots represents the NES. C GO enrichment analysis of genes upregulated in the ICD subtype 1 group compared with the ICD subtype 2 group. D GO enrichment analysis of genes downregulated in the ICD subtype 1 group compared with the ICD subtype 2 group. For C and D, “Gene ratio” is the percentage of total DEGs annotated with the given GO term. The size of the dots represents the number of DEGs associated with the GO term, and the colour of the dots represents the P-adjusted values

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Malaria Journal

ISSN: 1475-2875

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