Table 2 k13 mutations among samples collected during TES in the eight regions of Tanzania from 2016 to 2021
Year | Region | #Sequenced | k13* (%) | k13** (wild-type) (%) | k13** (mutant) (%) | k13 ** (SYN mutation) | k13** (NS mutation) |
|---|---|---|---|---|---|---|---|
2016 | Kigoma | 118 | 101 (85.6) | 95 (94.1) | 6 (5.9) | 3 (2-R471 & C469) | 3 (2-Q613E &I416V) |
Morogoro | 104 | 96 (92.3) | 92 (95.8) | 4 (4.2) | 2 (R471 & R539) | 2 (E433D & A578S) | |
Pwani | 92 | 79 (85.9) | 75 (94.9) | 4 (5.1) | 4 (P417, C469 & 2-V487 | 0 | |
Tanga | 109 | 100 (91.7) | 95 (95.0) | 5 (5.0) | 4 (P417 & 3-C469) | 1 (R471S) | |
2018 | Kigoma | 111 | 96 (86.5) | 96 (100.0) | 0 (0.0) | 0 | 0 |
Morogoro | 99 | 87 (87.9) | 84 (96.6) | 3 (3.4) | 3 (G538 & 2-R539) | 0 | |
Pwani | 97 | 79 (81.4) | 76 (96.2) | 3 (3.8) | 3 (S624) | 0 | |
Tanga | 119 | 97 (81.5) | 97 (100.0) | 0 (0.0) | 0 | 0 | |
2019 | Mbeya | 95 | 90 (94.7) | 86 (95.6) | 4 (4.4) | 4 (P417, 2- C469 & R539) | 0 |
Mtwara | 93 | 88 (94.6) | 84 (95.5) | 4 (4.5) | 3 (C469 & 2-F505) | 1 (P475S) | |
Tabora | 111 | 96 (86.5) | 94 (98.0) | 2 (2.0) | 2 (P417) | 0 | |
Mwanza | 104 | 79 (76.0) | 79 (100.0) | 0 (0.0) | 0 | 0 | |
2020 | Pwani | 97 | 83 (85.6) | 82 (98.8) | 1 (1.2) | 1 (R539) | 0 |
Kigoma | 103 | 70 (68.0) | 66 (94.3) | 4 (5.7) | 4 (P417) | 0 | |
Morogoro | 96 | 95 (99.0) | 91 (95.8) | 4 (4.2) | 3 (P417) | 1 (R622I) | |
Tanga | 116 | 100 (86.2) | 100 (100.0) | 0 (0.0) | 0 | 0 | |
2021 | Mbeya | 48 | 43 (89.6) | 43 (100.0) | 0 (0.0) | 0 | 0 |
Mtwara | 87 | 87 (100.0) | 87 (100.0) | 0 (0.0) | 0 | 0 | |
Mwanza | 106 | 96 (90.6) | 96 (100.0) | 0 (0.0) | 0 | 0 | |
Tabora | 110 | 107 (97.3) | 106 (99.1) | 1 (0.9) | 1 (Y558) | 0 | |
Total | Â | 2015 | 1769 (87.8) | 1724 (97.5) | 45 (2.5) | 37 (2.1%) | 8 (0.4%) |