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Table 2 PCR uncorrected treatment responses for artemether-lumefantrine or dihydroartemisinin-piperaquine by day 28 and 42 days

From: Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine and prevalence of molecular markers of anti-malarial drug resistance in children in Togo in 2021

PCR-uncorrected Outcome

Lost/ withdrawn

Per-protocol analysis

Kaplan Meier Cure rate

ETFa

LCFb

LTFc

ACPRd

No (%)

No

% (CI 95%)

No

% (CI 95%)

No

% (CI 95%)

No

% (CI 95%)

% (CI 95%)

Kouvé site (Day 28)

 ALe (n = 97)

8 (8.2)

0

0.0 (0.0–4.1)

4

4.5 (1.2–11.1)

6

6.7 (2.5–14.1)

79

88.8 (80.3–94.5)

88.9 (80.4–93.9)

 DPf (n = 95)

5 (5.3)

0

0.0 (0.0–4.0)

0

0.0 (0.0–4.0)

1

1.1 (0.0–6.0)

89

98.9 (94.0–100)

98.9 (92.7–99.8)

Anié site (Day 28)

 ALe (n = 82)

3 (3.7)

0

0.0 (0.0–4.6

4

5.1 (1.4–12.5

5

6.3 (2.1–14.2)

70

88.6 (79.5–94.7)

88.6 (79.3–93.9)

 DPf (n = 83)

7 (8.4)

0

0.0 (0.0–4.7)

1

1.3 (0–7.1)

1

1.3 (0–7.1)

74

97.4 (90.8–99.7

97.4 (89.9–99.3)

Kouvé site (Day 42)

 ALe (n = 97)

8 (8.2)

0

0.0 (0.0–4.1)

6

6.7 (2.5–14.1)

10

11.2 (5.5–19.7)

73

82.0 (72.5–89.4)

82.2 (72.6–88.7)

 DPf (n = 95)

6 (6.3)

0

0.0 (0.0–4.1)

2

2.2 (0.3–7.9)

5

5.6 (1.8–12.6)

82

92.1 (84.5–96.8)

92.3 (84.5–96.2)

Anié site (Day 42)

 ALe (n = 82)

3 (3.7)

0

0.0 (0.0–4.6)

5

6.3 (2.1–14.2)

8

10.1 (4.5–19.0)

66

83.5 (73.5–90.9)

83.5 (73.4–90.1)

 DPf (n = 83)

7 (8.4)

0

0.0 (0.0–4.7)

1

1.3 (0.0–7.1)

3

3.9 (0.8–11.1)

72

94.7 (87.1–98.5)

94.7 (86.6–98.0)

  1. aearly treatment failure
  2. blate clincal failure
  3. clate parasitological failure
  4. dadequate clinical and parasitological response
  5. eartemether-lumefantrine
  6. fdihydroartemisinin-piperaquine