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Table 3 PCR-corrected treatment responses for artemether-lumefantrine or dihydroartemisinin-piperaquine by day 28 and 42 days

From: Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine and prevalence of molecular markers of anti-malarial drug resistance in children in Togo in 2021

PCR-corrected Outcome

Lost/ withdrawn

Reinfection/Unknowna

Per-protocol analysis

Kaplan Meier Cure rate

Total analysable

LCFb

LTFc

ACPRd

 

No(%)

No(%)

No

%(CI 95%)

No

%(CI 95%)

No

%(CI 95%)

%(CI 95%)

Kouvé site (Day 28)

 ALe (n = 97)

8(8.2)

8(8.2)

81

1

1.2(0.0–6.7)

1

1.2(0.0–6.7)

79

97.5(91.4–99.7)

97.8(91.3–99.4)

 DPf (n = 95)

5(5.3)

1(1.1)

89

0

0.0(0.0–4.1)

0

0.0(0.0–4.1)

89

100(95.9–100)

100

Anié site (Day 28)

 ALe (n = 82)

3(3.7)

8(9.8)

71

1

1.4(0.0–7.6)

0

0.0(0.0–5.1)

70

98.6(92.4–100)

98.7(91.2–99.8)

 DPf (n = 83)

7(8.4)

2(2.4)

74

0

0.0(0.0–4.9)

0

0.0(0.0–4.9)

74

100(95.1–100)

100

Kouvé site (Day 42)

 ALe (n = 97)

8(8.2)

13(13.4)

76

1

1.3(0.0–7.1)

2

2.6(0.3–9.2)

73

96.1(88.9–99.2)

96.4(89.1–98.8)

 DPf (n = 95)

6(6.3)

6(6.3)

83

0

0.0(0.0–4.3)

1

1.2(0.0–6.5)

82

98.8(93.5–100)

98.9(92.1–99.8)

Anié site (Day 42)

 ALe (n = 82)

3(3.7)

11(13.4)

68

1

1.5(0.0–7.9)

1

1.5(0.0–7.9)

66

97.1(89.8–99.6)

97.3(89.5–99.3)

 DPf (n = 83)

7(8.4)

4(4.8)

72

0

0.0(0.0–5.0)

0

0.0(0.0–5.0)

72

100(95.0–100)

100

  1. asamples with inconclusive PCR result: 3 in Kouvé and 2 in Anié AL treatment groups
  2. blate clincal failure
  3. clate parasitological failure
  4. dadequate clinical and parasitological response
  5. eartemether-lumefantrine
  6. fdihydroartemisinin-piperaquine