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Table 2 Parasitological and clinical outcomes of enrolled patients

From: Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in mainland Tanzania, 2019

Outcomes

Karume (n = 88)

Simbo (n = 88)

Ipinda (n = 88)

Nagaga (n = 85)

n (%; 95% CI)

n (%; 95% CI)

n (%), 95% CI)

n (%; 95% CI)

PCR Uncorrected

    

 ACPR

65(73.9; 63.6–82.1)

67(80.7; 70.7–87.9)

80(92.0;83.8–96.2)

77(90.6;82.1–95.3)

 LCF

10(11.4; 6.2–20.0)

6(7.2;3.2–15.3)

2(2.3; 0.6–8.9)

2(2.4; 0.6–9.1)

 LPF

13(14.8; 8.7–24.0)

10(12.1; 7–21.1)

5(5.7; 2.4–13.2)

6(7.1; 3.2–15.0)

Excluded

    

 Lost to follow-up

–

3

–

–

 Withdrawn

–

2

1

–

Cumulative cure rate (Kaplan–Meier) (95% CI)

73.9

(63.3–81.8)

80.8

(70.6–87.8)

92.0

(83.9–96.1)

90.6

(82.1–95.2)

PCR corrected

    

 ACPR

65(97.0; 88.6–99.3)

67(100.0)

80(98.8; 91.5–99.8)

77(100.0)

 LCF

0(0)

0(0)

0(0)

0(0)

 LPF

2(3.0; 0.7–11.4)

0(0)

1(1.2; 0.2–8.5)

0(0)

Total analysed

67

67

81

77

Excluded

    

 New Infection

21

16

5

7

 Undetermined

0

0

1

1

 Loss to follow-up/withdrawn

0

5

1

0

 Total excluded

21

21

7

8

 Cumulative cure rate (Kaplan–Meier), 95% CI

97.7 (91.0–99.4)

100

98.9 (92.2–99.8)

100

  1. ETF Early Treatment Failure, LPF Late Parasitological Response, LCF Late Clinical Failure, ACPR Adequate Clinical and Parasitological Response